Answer 1:
In the given paper the author have hypothesized that incorporation of antioxidants like vitamin C and beta carotene would be helpful in the reduction of cancers through the inhibition of carcinogenic compounds like nitrosamines, superoxide. Thus the differences between the intakes of the nutrients have been measured through their effect on mortality (Bjlakovic, Nikolva and Gluud 2014).
The outcomes of the study have been received in accordance with the hypothesis. There is a negative correlation between the consumption of food rich in antioxidants and the risk of cancers (Boland et al. 2015). The present study has tried to estimate the differences in the intake of Vit C and Beta carotene as well as both on the average deaths of people through a cohort study. The studies have been conducted among middle aged men in US.
Answer 2:
The relation between the unexposed individuals, people not affected with cancer in this case have been compared with variable like VitC, β Carotene and both. Thus mortality rates have been statistically determined and examined for establishing the relation between the various variables and the subsequent risk of developing cancer.
Answer 3:
The given paper is a prevalence study. A prevalence study is a kind of observational study which involves analysis of data from the particular population along with a representative subset especially at a specific point of time (Oh et al. 2016). In this paper, the association bet Vit C and β carotene uptakes have been assessed among a population of middle aged men within a cohort study between 1958, 1959. Thus, the prevalence of risks due to cancer has been studied.
Answer 4:
Here a prospective study has been conducted as it has considered the outcomes of the experiment involving the development of the diseases during a particular study period which relates to factors like suspended risks. Here the risk of death has been considered.
Answer 5:
This study has been an open one as the participants of the particular company, Western Electric Study has been selected. Thus the population of the workers in the company is dynamic as the people might change the company and the required population might not be specific. Thus, individuals contributing to the cohort study might not be followed through time (Hwang et al. 2014).
Answer 6:
Answer 7:
The subsequent intakes of Vitamin C and Beta carotene between smokers and non-smokers have not produced significant results. A mortality ratio of 0.58 has been found for dietary intakes of 50 mg/day of antioxidants but the difference with respect to smokers and non-smokers have not been explained.
Answer 8:
The odds have been 0.79 (0.60-1.04) for deaths from coronary diseases. The odds of the death due to beta carotene with an increased intake of 3mg/day of vitamin C is 0.78 (0.58-1.03) die to deaths from coronary diseases. These results have been after 5 years of follow up. Overall there has been a 95% probability of cancer.
Answer 9:
Answer 10:
In the chart of vitamin C the difference between the mortality rates among smoker suffering from cancer is 34-28 for deaths and 0.82-0.52 for the relative risks. For the chart of beta carotene the number of deaths has been 28 compared to 6 and the risks has been 0.66 than 0.73.
Answer 11.
The odds of being a current smoker among all causes are 0.63. The odds here is considered as the probability for acquiring the diseases.
Answer 12.
The general result of the study has been a reduction in the relative risks of cancer with an increased dose of antioxidants like vitamin C and Beta carotene per day (Valdez-Ramos et al. 2015). It can be done through the incorporation of two oranges for Vit C and two carrots in the diet. For a 31 % lower risk of deaths from cancer.
Answer 13
Answer 14
Answer 15
References
Bjelakovic, G., Nikolova, D. and Gluud, C., 2014. Antioxidant supplements and mortality. Current Opinion in Clinical Nutrition & Metabolic Care, 17(1), pp.40-44.
Bolland, M.J., Grey, A., Gamble, G.D. and Reid, I.R., 2014. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. The lancet Diabetes & endocrinology, 2(4), pp.307-320.
Hwang, A.C., Peng, L.N., Wen, Y.W., Tsai, Y.W., Chang, L.C., Chiou, S.T. and Chen, L.K., 2014. Predicting all-cause and cause-specific mortality by static and dynamic measurements of allostatic load: a 10-year population-based cohort study in Taiwan. Journal of the American Medical Directors Association, 15(7), pp.490-496.
Oh, C.M., Won, Y.J., Jung, K.W., Kong, H.J., Cho, H., Lee, J.K., Lee, D.H. and Lee, K.H., 2016. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2013. Cancer research and treatment: official journal of Korean Cancer Association, 48(2), p.436.
Pandey, D.K., Shekelle, R., Selwyn, B.J., Tangney, C. and Stamler, J., 1995. Dietary vitamin C and β-carotene and risk of death in middle-aged men: the Western Electric study. American journal of epidemiology, 142(12), pp.1269-1278.
Sytkowski, P.A., D’Agostino, R.B., Belanger, A. and Kannel, W.B., 1996. Sex and time trends in cardiovascular disease incidence and mortality: the Framingham Heart Study, 1950–1989. American journal of epidemiology, 143(4), pp.338-350.
Valdés-Ramos, R., Ana Laura, G.L., Beatriz Elina, M.C. and Alejandra Donaji, B.A., 2015. Vitamins and type 2 diabetes mellitus. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 15(1), pp.54-63.
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